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Preliminary reference intervals of Glycated Albumin in healthy Caucasian pregnant women.

Authors
  • Agnello, Luisa1
  • Lo Sasso, Bruna2
  • Scazzone, Concetta1
  • Giglio, Rosaria Vincenza1
  • Gambino, Caterina Maria1
  • Bivona, Giulia1
  • Pantuso, Michele1
  • Ciaccio, Anna Maria3
  • Venezia, Renato4
  • Vidali, Matteo5
  • Ciaccio, Marcello6
  • 1 Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy. , (Italy)
  • 2 Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy; Department of Laboratory Medicine, University Hospital "P. Giaccone", Palermo, Italy. , (Italy)
  • 3 University of Palermo, Palermo, Italy. , (Italy)
  • 4 Unit of Gynaecology and Obstetrics, Department of Science for Health Promotion and Mother to Child Care "G. D'Alessandro", University of Palermo, Italy. , (Italy)
  • 5 Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. , (Italy)
  • 6 Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy; Department of Laboratory Medicine, University Hospital "P. Giaccone", Palermo, Italy. Electronic address: [email protected] , (Italy)
Type
Published Article
Journal
Clinica chimica acta; international journal of clinical chemistry
Publication Date
May 12, 2021
Volume
519
Pages
227–230
Identifiers
DOI: 10.1016/j.cca.2021.05.009
PMID: 33989612
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Glycated albumin (GA) could represent a useful biomarker in pregnant women for diagnosing and monitoring gestational diabetes mellitus (GDM). The establishment of reference intervals (RI) is mandatory before assessing its clinical usefulness. The RIs of GA in healthy pregnant women are not well defined. The aim of the current study was to establish the RI in a cohort consisting of Caucasian pregnant women without overt diabetes mellitus or gestational diabetes mellitus. The study included 183 healthy pregnant women. GA was measured on plasma by an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany). The RI was calculated by the non-parametric and robust methods. The RI of GA in the whole population was 10.16% (90%CI 9.60-10.70) and 15.44% (90%CI 14.90-16.90). GA levels decreased during pregnancy, with lower levels in the third trimester: 10.11 (90%CI 9.48-10.79) and 15.72 (90%CI 15.15-16.27) in the first trimester, 10.49 (90%CI 10.05-10.96) and 15.49 (90%CI 15.05-15.92) in the second trimester, 9.84 (90%CI 9.50-10.22) and 14.57 (90%CI 14.11-15.01) in the third trimester. Finally, a weak negative correlation was found between GA levels and body mass index. This is the first study establishing the RIs of GA in Caucasian healthy pregnant women. Copyright © 2021. Published by Elsevier B.V.

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