Foodborne diseases remain an important public health problem in the United States. The Foodborne Diseases Active Surveillance Network (FoodNet) of CDC's Emerging Infections Program collects data from 10 U.S. states on diseases caused by enteric pathogens transmitted commonly through food. FoodNet is an active, population-based surveillance system for these laboratory-confirmed infections. This report describes preliminary surveillance data for 2008 and trends since 1996. In 2008, the estimated incidence of infections caused by Campylobacter, Cryptosporidium, Cyclospora, Listeria, Shiga toxin-producing Escherichia coli (STEC) O157, Salmonella, Shigella, Vibrio, and Yersinia did not change significantly when compared with the preceding 3 years. For most infections, incidence was highest among children aged <4 years, whereas the percentage of persons hospitalized and the case fatality rate were highest among persons aged >/=50 years. None of the Healthy People 2010 targets for reduction of foodborne pathogens (objective 10-1) were reached in 2008. The lack of recent progress points to gaps in the current food safety system and the need to continue to develop and evaluate food safety practices as food moves from the farm to the table.