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Preliminary evidence of the presence of lymphatic vessels immunoreactive for D2-40 and Prox-1 in human pterygium.

Authors
  • Cimpean, Anca Maria
  • Poenaru Sava, Mihai
  • Raica, Marius
  • Ribatti, Domenico
Type
Published Article
Journal
Oncology Reports
Publisher
Spandidos Publications
Publication Date
November 2011
Volume
26
Issue
5
Pages
1111–1113
Identifiers
DOI: 10.3892/or.2011.1342
PMID: 21667034
Source
Medline
License
Unknown

Abstract

Human pterygium is a benign fibrovascular outgrowth of the corneo-conjunctival junction, characterized by tissue remodeling, cellular proliferation, angiogenesis and inflammation. No data are available concerning the presence of lymphatic vessels in this pathological condition. The aim of this study was to evaluate by immunohistochemistry, using antibodies against D2-40, Prox-1 and Ki-67, the presence and the proliferative activity of lymphatic vessels in human pterygium. An increased lymphatic microvessel density was observed in the human pterygium compared to the normal conjunctiva. Moreover, D2-40-positive lymphatic endothelial cells were also actively proliferating, as assessed by Ki-67 immunostaining, while in normal conjunctiva proliferating lymphatic endothelial cells were not detectable. Overall, these data clearly indicate the presence of active proliferating lymphatic vessels in human pterygium, suggesting that active lymphangiogenesis occurs in this pathological condition.

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