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Prehabilitation programs for cancer patients: a systematic review of randomized controlled trials (protocol)

  • Meneses-Echávez, Jose F.1, 2
  • Loaiza-Betancur, Andrés F.3
  • Díaz-López, Víctor3
  • Echavarría-Rodríguez, Andrés M.3
  • 1 Norwegian Institute of Public Health, Sandakerveien 24C, Building D11, 4th Floor, Office 434, Oslo, Norway , Oslo (Norway)
  • 2 Universidad Santo Tomás, Bogotá, Colombia , Bogotá (Colombia)
  • 3 University of Antioquia, Medellín, Colombia , Medellín (Colombia)
Published Article
Systematic Reviews
BioMed Central
Publication Date
Feb 13, 2020
DOI: 10.1186/s13643-020-1282-3
Springer Nature


BackgroundAround twenty million new cases and ten million of deaths were attributed to cancer in 2018. Physical exercise, as main component of prehabilitation programs, has been associated with clinical improvements in aerobic capacity, muscular strength, gait speed, and fewer postoperative complications. This systematic review aims to determine the benefits and harms of prehabilitation programs, mainly composed of physical exercise, compared with standard care for cancer patients.Methods/designA librarian will systematically search for randomized controlled trials in the following databases: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (PubMed), and EMBASE. Two independent reviewers will independently screen the retrieved references, appraise the methodological quality of the included studies, and extract data. If possible, we will pool the data. We will evaluate the completeness of reporting of prehabilitation programs by using the CERT checklist, and the GRADE approach will be used to evaluate the quality of the evidence.DiscussionThis systematic review will determine the benefits and harms of prehabilitation programs for cancer patients. We will provide a complete appraisal of the quality of the evidence, our confidence in the results, and completeness of reporting of the exercise interventions evaluated in the prehabilitation programs. Findings from this review will assist health care providers, patients, decision-makers, and international organizations to make informed decisions in this field.Systematic review registrationPROSPERO CRD42019125658

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