Affordable Access

Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin.

Authors
  • Shingo, Tetsuro
  • Gregg, Christopher
  • Enwere, Emeka
  • Fujikawa, Hirokazu
  • Hassam, Rozina
  • Geary, Colleen
  • Cross, James C
  • Weiss, Samuel
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Jan 03, 2003
Volume
299
Issue
5603
Pages
117–120
Identifiers
PMID: 12511652
Source
Medline
License
Unknown

Abstract

Neurogenesis occurs in the olfactory system of the adult brain throughout life, in both invertebrates and vertebrates, but its physiological regulation is not understood. We show that the production of neuronal progenitors is stimulated in the forebrain subventricular zone of female mice during pregnancy and that this effect is mediated by the hormone prolactin. The progenitors then migrate to produce new olfactory interneurons, a process likely to be important for maternal behavior, because olfactory discrimination is critical for recognition and rearing of offspring. Neurogenesis occurs even in females that mate with sterile males. These findings imply that forebrain olfactory neurogenesis may contribute to adaptive behaviors in mating and pregnancy.

Report this publication

Statistics

Seen <100 times