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Pregnancy rate is significantly higher in in vitro fertilization procedure with spermatozoa isolated from nonliquefying semen in which liquefaction is induced by alpha-amylase.

Authors
  • Vermeiden, J P
  • Bernardus, R E
  • ten Brug, C S
  • Statema-Lohmeijer, C H
  • Willemsen-Brugma, A M
  • Schoemaker, J
Type
Published Article
Journal
Fertility and Sterility
Publisher
Elsevier
Publication Date
Jan 01, 1989
Volume
51
Issue
1
Pages
149–152
Identifiers
PMID: 2783410
Source
Medline
License
Unknown

Abstract

In 115 patients (group I) in which normal liquefaction of semen occurred, the fertilization rate of the yielded oocytes was 71.2% after standard in vitro fertilization procedure, and the viable pregnancy rate per patient per cycle was 13.0%. In a comparable group of 26 patients (group II), in which semen liquefaction did not occur spontaneously, alpha-amylase was added in order to liquefy the semen. In this group, the fertilization rate was 86.7% of the yielded oocytes, and the viable pregnancy rate per patient per cycle was 26.9% (P less than 0.05). It is concluded that alpha-amylase can be of use to liquefy nonliquefying semen, and that the resultant spermatozoa have a positive effect on pregnancy results.

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