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Pregnancy and perinatal complications associated with risks for common psychiatric disorders in a population-based sample of female twins.

Authors
  • Foley, D L
  • Thacker, L R 2nd
  • Aggen, S H
  • Neale, M C
  • Kendler, K S
Type
Published Article
Journal
American journal of medical genetics
Publication Date
Jul 08, 2001
Volume
105
Issue
5
Pages
426–431
Identifiers
PMID: 11449394
Source
Medline
License
Unknown

Abstract

The association between pregnancy and perinatal complications (PPCs) and risks for adult psychiatric disorders other than psychoses has received relatively limited attention. In this study, we aim to characterize the associations between PPCs and risks for anxiety, affective, substance use, and eating disorders in a population-based sample of twins. Personal interviews were conducted with 1,806 female twin subjects to assess their lifetime history of alcoholism, anorexia nervosa, bulimia nervosa, generalized anxiety disorder, major depression, panic disorder, simple phobias, and social phobias. PPCs were retrospectively assessed at personal interview with the subject's parents. The associations between PPCs and risks for psychiatric disorders are characterized using logistic regression. In this sample of twins, gestational age is associated with a significantly increased risk for anorexia nervosa and pregnancy complications are associated with a significantly increased risk for both anorexia nervosa and bulimia nervosa. Pregnancy and perinatal complications may be associated with an increased risk for eating disorders in women.

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