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Pregnancy induces expression of cPLA2 in ovine uterine artery but not systemic artery endothelium.

Authors
  • Di, T
  • Sullivan, J A
  • Rupnow, H L
  • Magness, R R
  • Bird, I M
Type
Published Article
Journal
Journal of the Society for Gynecologic Investigation
Publication Date
Jan 01, 1999
Volume
6
Issue
6
Pages
301–306
Identifiers
PMID: 10643582
Source
Medline
License
Unknown

Abstract

cPLA2 was expressed throughout the endothelium and VSM of both uterine and omental arteries, but only in UA endothelium was pregnancy associated with elevated cPLA2 expression. The lack of change in cPLA2 expression with the ovarian cycle or in ovariectomized animals, even after prolonged treatment with E2 beta, P4, or E2 beta/P4 combined suggests this pregnancy-induced increase in cPLA2 may not be estrogen and/or progesterone dependent.

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