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Preferential involvement of larger vessels in a rat model of diabetes-induced graft vasculopathy.

Authors
  • Cantin, Bernard
  • Zhu, Dening
  • Wen, Peizhong
  • Panchal, Shyam N
  • Gwathmey, Judith K
  • Reaven, Gerald M
  • Valantine, Hannah A
Type
Published Article
Journal
The Journal of Heart and Lung Transplantation
Publisher
Elsevier
Publication Date
Sep 01, 2002
Volume
21
Issue
9
Pages
1040–1043
Identifiers
PMID: 12231376
Source
Medline
License
Unknown

Abstract

Using previously described models of diabetes-induced transplant coronary artery atherosclerosis (TxCAD), we quantitatively assessed TxCAD using computer-assisted morphometric measurements. More than 95% of the evaluated vessels were intramyocardial vessels. The first and last tertile of the vessel size distribution were evaluated for the presence of TxCAD. Severe TxCAD, defined as a luminal occlusion > or =75%, was more prevalent in the larger vessels. We observed a differential involvement based on vessel size in diabetes-induced TxCAD.

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