Affordable Access

Access to the full text

Preferences of women with epithelial ovarian cancer for aspects of genetic testing

Authors
  • Davidson, Brittany A.
  • Ehrisman, Jessie
  • Reed, Shelby D.
  • Yang, Jui-Chen
  • Buchanan, Adam
  • Havrilesky, Laura J.
Type
Published Article
Journal
Gynecologic Oncology Research and Practice
Publisher
BioMed Central
Publication Date
Jan 22, 2019
Volume
6
Issue
1
Identifiers
DOI: 10.1186/s40661-019-0066-8
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundAlthough genetic testing is recommended for women with epithelial ovarian cancer (EOC), little is known about patient preferences for various testing options. We measured relative preferences for attributes of testing in women with EOC referred for genetic counseling.MethodsSubjects were recruited to participate in a discrete-choice-experiment survey to elicit preferences for attributes of genetic testing: out-of-pocket cost ($0, $100, $250, or $1000), probability of a deleterious mutation (60, 80%, or 88%), probability of a variant of uncertain significance (VUS) result (5, 20%, or 40%), sample requirements (blood or saliva), and turn-around time (1, 2 or 4 weeks). Subjects viewed educational videos followed by a series of choices between pairs of constructed genetic tests with varying attribute levels. Random-parameters logit was used to estimate preference weights for attribute levels. Relative importance weights and money-equivalent values were calculated.ResultsNinety-four patients were enrolled; 68 (76.4%) presented for genetic counseling. Test cost was the most important attribute to subjects (importance weight = 41 out of 100) followed by probability to detect deleterious mutations (36) and probability of a VUS result (20). Sample requirements and turnaround time did not drive test choices. Subjects were willing to pay an additional $155 and $70 for incremental 5% improvements in the probability to detect deleterious mutations and probability of a VUS result. At genetics consultation, 55/68 (80.9%) subjects chose multigene testing.ConclusionsLow out-of-pocket cost, high probability of detecting deleterious mutations and high probability of a VUS result are preferred by patients with EOC considering genetic testing.

Report this publication

Statistics

Seen <100 times