Affordable Access

Access to the full text

Preeclampsia – Prediction and Monitoring Factors

Authors
  • Rudic, Jovan
  • Raicevic, Sasa1
  • Babic, Goran2,
  • 1 Medical faculty, Department of Gynecology and obstetrics, Montenegro , (Montenegro)
  • 2 Faculty of Medical Sciences, Department of Gynecology and obstetrics, Serbia , (Serbia)
Type
Published Article
Journal
Serbian Journal of Experimental and Clinical Research
Publisher
Sciendo
Publication Date
Dec 31, 2019
Volume
20
Issue
4
Pages
287–294
Identifiers
DOI: 10.2478/sjecr-2018-0026
Source
De Gruyter
Keywords
License
Green

Abstract

Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality, usually characterized by hypertension and proteinuria. Despite high incidence of preeclampsia the pathophysiological basis of preeclampsia is still not clear and there are a number of mechanisms and signaling pathways that intertwine. It is very important to develop specific and reliable predictive algorithms in order to enable early initiation of therapy due to facts that incidence of preeclampsia has upward trend and that cause adverse maternal and fetal outcome. Some of the most commonly used methods for prediction of preeclampsia include uterine artery Doppler velocimetry, determination of some microRNA, such as miR-210, and assessment of various pro-angiogenic and anti-angiogenic factors from blood. Angiogenic factors that possibly have most important role in pathogenesis of preeclampsia are vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), which promote angiogenesis, and soluble fms-like tyrosine kinase-1 (sFlt1) and soluble form of endoglin (s-Eng), which exhibit anti-angiogenic properties. Aggravating circumstance is that preeclampsia has heterogeneous origin, and due to this fact, the value of individual markers can vary significantly. There is a constant tendency for creating comprehensive algorithm for prediction of preeclampsia which would be sufficiently specific and sensitive, and in the same time cheap and available. In that sense, new clinical studies are needed to show the most effective combination of parameters in the predeclampsia prediction.

Report this publication

Statistics

Seen <100 times