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Predictors of response to alprazolam and placebo in patients with panic disorder.

Authors
  • Woodman, C L
  • Noyes, R Jr
  • Ballenger, J C
  • Lydiard, R B
  • Sievers, G
  • Mihalko, D
Type
Published Article
Journal
Journal of Affective Disorders
Publisher
Elsevier
Publication Date
Jan 01, 1994
Volume
30
Issue
1
Pages
5–13
Identifiers
PMID: 8151049
Source
Medline
License
Unknown

Abstract

Date from a panic disorder treatment study with 506 patients, comparing alprazolam and placebo in a double-blind manner for 8 weeks, were analyzed to identify demographic and clinical characteristics of the patients that might predict response to treatment. The strongest predictors of response to alprazolam were age over 40, and lower baseline levels of anxiety and phobic symptoms. Predictors of response to placebo were weaker and, in addition to lower levels anxiety and panic attacks, included a lack of previous psychiatric treatment.

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