Affordable Access

Access to the full text

Predictors of Prolonged Laparoscopic Radical Prostatectomy and the Creation of a Scoring System for the Duration

Authors
  • Chen, Shao-Hao1
  • Ke, Zhi-Bin1
  • Wu, Yu-Peng1
  • Chen, Dong-Ning1
  • Yu, Xiang1
  • Chen, Yu2, 3
  • Wei, Yong1
  • Zheng, Qing-Shui1
  • Xue, Xue-Yi1
  • Xu, Ning1
  • 1 The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005
  • 2 Cancer Bio-Immunotherapy Center, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou
  • 3 Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou
Type
Published Article
Journal
Cancer Management and Research
Publisher
Dove Medical Press Ltd.
Publication Date
Sep 04, 2020
Volume
12
Pages
8005–8014
Identifiers
DOI: 10.2147/CMAR.S265480
PMID: 32943933
PMCID: PMC7481309
Source
PubMed Central
Keywords
License
Green

Abstract

Purpose To identify the relevant factors, and create and validate a predictive scoring system for the duration of laparoscopic radical prostatectomy (LRP). Patients and Methods We retrospectively analyzed clinicopathological data from 436 patients who underwent LRP between January 2014 and January 2019, of whom 304 cases were used as a model creation group and 132 were used as a validation group. Uni/multivariate linear regression analysis was performed to determine the predictors of the duration of the procedure and a novel scoring system was created using these predictors. External validation of the scoring system was performed. The Hosmer–Lemeshow test was used to determine the goodness-of-fit of the model and calibration plots were created for visual assessment. Results “Prolonged duration” was defined as a duration of the procedure that was longer than the mean (>150 min) duration. Multivariate analysis showed that body mass index (BMI), prostate volume, intravesicular protrusion of the prostate (IPP), the ratio of the cross-sectional areas of the prostate and the Retzius space (P/R), pelvic lymph node dissection, and neurovascular bundle (NVB) preservation were significant predictors of prolonged duration. A scoring system that included these six parameters was created and the area under the curve achieved during receiver operating characteristic analysis using this scoring system was 0.874 (95% confidence interval [CI]: 0.836–0.913). The Hosmer–Lemeshow test showed that the scoring system was well calibrated (X2=5.339, P =0.376). The external validation showed that the model had high predictive accuracy (AUC=0.835, 95% CI: 0.764–0.906) and goodness-of-fit (X2=4.401, P =0.493). Conclusion The following factors were significantly associated with prolonged duration of laparoscopic radical prostatectomy: BMI, prostate volume, IPP, P/R, pelvic lymph node dissection, and NVB preservation. The novel scoring system created can be used to accurately predict the duration of the procedure, assess the difficulty of surgery, and improve perioperative efficiency.

Report this publication

Statistics

Seen <100 times