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Predictive Value of Neutrophil Count for Postoperative Complications in Children after Surgery of Perforated Appendicitis

Authors
  • Marjanovic, Vesna1, 2
  • Budic, Ivana1, 2
  • Jankovic-Velickovic, Ljubinka3, 4
  • Stevic, Marija5, 6
  • Kostic, Milos1
  • Simic, Dusica5, 6
  • 1 University of Nis, Serbia , (Serbia)
  • 2 Clinic for Anesthesia and Intensive Therapy, Clinical Centre Nis, Serbia , (Serbia)
  • 3 Faculty of Medicine, University of Nis, Serbia , (Serbia)
  • 4 Centre of Pathology, Clinical Centre Nis, Serbia , (Serbia)
  • 5 University of Belgrade, Serbia , (Serbia)
  • 6 University Children’s Hospital, Serbia , (Serbia)
Type
Published Article
Journal
Revista Romana de Medicina de Laborator
Publisher
De Gruyter Open Sp. z o.o.
Publication Date
Jan 01, 2021
Volume
29
Issue
1
Pages
77–84
Identifiers
DOI: 10.2478/rrlm-2021-0008
Source
De Gruyter
Keywords
License
Green

Abstract

Introduction: Perforated appendicitis (PA) in children is associated with a considerable risk for postoperative complications (POCs) such as wound infection and intra-abdominal abscess. The aim of this study was to determine the diagnostic accuracy of hematological parameters in the early POC detection in children after PA surgery. Materials and Methods: The study enrolled 71 patients with PA divided into two groups: 14 patients with POC (POC+ group) and 57 patients without POC (POC− group). Clinical and hematological parameters were followed preoperatively, prior to the surgery (PRO) and postoperatively on day 2 (POD2) and day 4 (POD4). Results: The POC+ group had longer duration of higher axillar temperature as well as extended intensive and inpatient care. This group also had a significantly lower absolute neutrophil count ratio between POD2 and POD4. According to the receiver operating characteristic curve analysis, relative neutrophil count on POD4 higher than 71.8% and the ratio of absolute neutrophil count between POD2 and POD4 lower than 44.5% were found to be useful for predicting POC. Conclusion: Absolute neutrophil count ratio between POD2 and POD4 and relative neutrophil count at POD4 could be efficient in identifying children at higher risk of developing POC after PA surgery.

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