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Predictive and prognostic molecular markers for cancer medicine.

Authors
  • Mehta, Sunali
  • Shelling, Andrew
  • Muthukaruppan, Anita
  • Lasham, Annette
  • Blenkiron, Cherie
  • Laking, George
  • Print, Cristin
Type
Published Article
Journal
Therapeutic advances in medical oncology
Publication Date
Mar 01, 2010
Volume
2
Issue
2
Pages
125–148
Identifiers
DOI: 10.1177/1758834009360519
PMID: 21789130
Source
Medline
Keywords
License
Unknown

Abstract

Over the last 10 years there has been an explosion of information about the molecular biology of cancer. A challenge in oncology is to translate this information into advances in patient care. While there are well-formed routes for translating new molecular information into drug therapy, the routes for translating new information into sensitive and specific diagnostic, prognostic and predictive tests are still being developed. Similarly, the science of using tumor molecular profiles to select clinical trial participants or to optimize therapy for individual patients is still in its infancy. This review will summarize the current technologies for predicting treatment response and prognosis in cancer medicine, and outline what the future may hold. It will also highlight the potential importance of methods that can integrate molecular, histopathological and clinical information into a synergistic understanding of tumor progression. While these possibilities are without doubt exciting, significant challenges remain if we are to implement them with a strong evidence base in a widely available and cost-effective manner.

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