Affordable Access

Access to the full text

Predictive molecular profiling in blood of healthy vasospastic individuals: clue to targeted prevention as personalised medicine to effective costs

Authors
  • Yeghiazaryan, Kristina1, 2
  • Flammer, Josef2, 3
  • Golubnitschaja, Olga1, 2
  • 1 Rheinische Friedrich-Wilhelms-University of Bonn, Department of Radiology, Sigmund-Freud-Str. 25, Bonn, 53105, Germany , Bonn (Germany)
  • 2 Preventive & Personalised Medicine, European Association for Predictive
  • 3 University of Basel, Department of Ophthalmology, Basel, Switzerland , Basel (Switzerland)
Type
Published Article
Journal
EPMA Journal
Publisher
BioMed Central
Publication Date
Jun 29, 2010
Volume
1
Issue
2
Pages
263–272
Identifiers
DOI: 10.1007/s13167-010-0032-3
Source
Springer Nature
Keywords
License
Yellow

Abstract

Paradigm change from late interventional approach to predictive diagnostics followed by targeted prevention before manifest pathology, presents innovative concept for advanced healthcare. Preselection of healthy but pathology-predisposed individuals is the primary task in the overall action. Vasospasm is a frequent syndrome defined as an inappropriate constriction or insufficient dilatation in microcirculation. Vasospastic individuals are considered as healthy subpopulation predisposed to several pathologies including neurodegeneration. Clinical observations, subcellular imaging and “gene hunting”-investigations provide evidence for vasospasm as predisposition to glaucoma; development of further related pathologies cannot be excluded. Predictive molecular-profiling in blood can specify individual predisposition for effective prevention.

Report this publication

Statistics

Seen <100 times