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Predictive modeling by the cerebellum improves proprioception.

Authors
Type
Published Article
Journal
Journal of Neuroscience
1529-2401
Publisher
Society for Neuroscience
Publication Date
Volume
33
Issue
36
Pages
14301–14306
Identifiers
DOI: 10.1523/JNEUROSCI.0784-13.2013
PMID: 24005283
Source
Medline

Abstract

Because sensation is delayed, real-time movement control requires not just sensing, but also predicting limb position, a function hypothesized for the cerebellum. Such cerebellar predictions could contribute to perception of limb position (i.e., proprioception), particularly when a person actively moves the limb. Here we show that human cerebellar patients have proprioceptive deficits compared with controls during active movement, but not when the arm is moved passively. Furthermore, when healthy subjects move in a force field with unpredictable dynamics, they have active proprioceptive deficits similar to cerebellar patients. Therefore, muscle activity alone is likely insufficient to enhance proprioception and predictability (i.e., an internal model of the body and environment) is important for active movement to benefit proprioception. We conclude that cerebellar patients have an active proprioceptive deficit consistent with disrupted movement prediction rather than an inability to generally enhance peripheral proprioceptive signals during action and suggest that active proprioceptive deficits should be considered a fundamental cerebellar impairment of clinical importance.

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