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The prediction value of Treg cell subtype alterations for glucocorticoid treatment in newly diagnosed primary immune thrombocytopenia patients.

Authors
  • Cheng, Luya1
  • Liu, Chanjuan2
  • Li, Feng3
  • Wu, Boting4
  • Min, Zhihui5
  • Chen, Pu6
  • Zhan, Yanxia7
  • Ke, Yang8
  • Hua, Fanli9
  • Yuan, Ling10
  • Sun, Lihua11
  • Chen, Hao12
  • Ji, Lili13
  • Cheng, Yunfeng14
  • 1 Department of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China. Electronic address: [email protected] , (China)
  • 2 Department of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China. Electronic address: [email protected] , (China)
  • 3 Department of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China; Department of Hematology, Zhongshan Hospital Qingpu Branch, Fudan Universiy, Shanghai 201700, China. Electronic address: [email protected] , (China)
  • 4 Department of Transfusion Medicine, Zhongshan Hospital Fudan University, Shanghai 200032, China. Electronic address: [email protected] , (China)
  • 5 Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Department of Thoracic Surgery, Zhongshan Hospital Xuhui Branch, Fudan University, Shanghai 200031, China. Electronic address: [email protected] , (China)
  • 6 Department of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China. Electronic address: [email protected] , (China)
  • 7 Department of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China. Electronic address: [email protected] , (China)
  • 8 Department of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China. Electronic address: [email protected] , (China)
  • 9 Department of Hematology, Zhongshan Hospital Qingpu Branch, Fudan Universiy, Shanghai 201700, China. Electronic address: [email protected] , (China)
  • 10 Department of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China. Electronic address: [email protected] , (China)
  • 11 Department of Hematology, Zhongshan Hospital Qingpu Branch, Fudan Universiy, Shanghai 201700, China. , (China)
  • 12 Department of Thoracic Surgery, Zhongshan Hospital Xuhui Branch, Fudan University, Shanghai 200031, China. Electronic address: [email protected] , (China)
  • 13 Department of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China. Electronic address: [email protected] , (China)
  • 14 Department of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China; Department of Hematology, Zhongshan Hospital Qingpu Branch, Fudan Universiy, Shanghai 201700, China; Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, 201500, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Thrombosis research
Publication Date
Sep 01, 2019
Volume
181
Pages
10–16
Identifiers
DOI: 10.1016/j.thromres.2019.07.001
PMID: 31323447
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder of which Treg cells are numerically or functionally deficient. It is known that human FoxP3+CD4+ T cells were composed of 3 phenotypically and functionally distinct subpopulations (resting Treg, rTreg; activated Treg, aTreg; and non-suppressive Treg, n-sTreg). The current study was aimed to determine whether these Treg subtypes are altered in ITP patients and the related potential clinical applications. Normal control volunteers and newly diagnosed ITP patients were enrolled in the study. The percentage of Treg cells' subtypes in peripheral blood was examined by flow cytometry before and after the glucocorticoid treatment. The IL-10 production by Treg subtypes was also examined. Treg cell subtypes of aTreg increased, rTreg decreased, and n-s Treg increased in newly diagnosed ITP patients' peripheral blood. The IL-10 production by respective Treg subtype didn't change after the treatment, and aTreg cells had the highest IL-10 yield. Patients who gained remission during follow-up had a higher aTreg cells' percentage than those who did not at the disease diagnosis. Tregs cell subtypes percentage was altered when ITP occurred. The increased aTreg cells at disease diagnosis might predict a better glucocorticoid treatment efficacy. Copyright © 2019. Published by Elsevier Ltd.

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