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Prediction of recurrence after treatment for high-grade cervical intraepithelial neoplasia: the role of human papillomavirus testing and age at conisation.

Authors
  • Verguts, J
  • Bronselaer, B
  • Donders, G
  • Arbyn, M
  • Van Eldere, J
  • Drijkoningen, M
  • Poppe, W
Type
Published Article
Journal
BJOG : an international journal of obstetrics and gynaecology
Publication Date
Nov 01, 2006
Volume
113
Issue
11
Pages
1303–1307
Identifiers
PMID: 16978225
Source
Medline
License
Unknown

Abstract

Persistence or clearance of HR-HPV DNA is an early valid prognostic marker of failure or cure after treatment for CIN2+ and is more accurate than cytology or section margin status at the time of conisation. The absence of HR-HPV DNA has a 100% negative predictive value. Higher age at conisation may be a previously unrecognised risk factor for recurrence.

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