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[Prediction of aminoglycoside nephrotoxicity].

Authors
  • Lucht, F
  • Peyramond, D
  • Robert, D
  • Vincent, P
Type
Published Article
Journal
La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris
Publication Date
Sep 30, 1982
Volume
58
Issue
35
Pages
2021–2025
Identifiers
PMID: 6293091
Source
Medline
License
Unknown

Abstract

Mechanism of aminoglycoside nephrotoxicity is yet unclear. Reduction of 20 p. cent of glomerular filtration initial value is observed in 10 p. cent of cases. Aminoglycoside nephrotoxicity appears to be related to high doses, to duration of treatment and also to individual factors such as age and preexisting renal impairment. No mean of predicting aminoglycoside nephrotoxicity without any error is available. Meanwhile, accurate measurement of glomerular filtration and of beta 2-microglobulin urinary elimination seems clinically more usefull for detection of impaired renal function than uneasy measurement of urinary enzyme excretion and than monitoring the aminoglycosides serum concentrations.

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