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Predicting tablet tensile strength with a model derived from the gravitation-based high-velocity compaction analysis data.

Authors
  • Tanner, Timo1
  • Antikainen, Osmo2
  • Pollet, Arne3
  • Räikkönen, Heikki2
  • Ehlers, Henrik2
  • Juppo, Anne2
  • Yliruusi, Jouko2
  • 1 Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland. Electronic address: [email protected] , (Finland)
  • 2 Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland. , (Finland)
  • 3 Faculty of Pharmaceutical Sciences, Ghent University, Belgium. , (Belgium)
Type
Published Article
Journal
International journal of pharmaceutics
Publication Date
May 14, 2019
Volume
566
Pages
194–202
Identifiers
DOI: 10.1016/j.ijpharm.2019.05.024
PMID: 31100384
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In the present study, a model was developed to estimate tablet tensile strength utilizing the gravitation-based high-velocity (G-HVC) method introduced earlier. Three different formulations consisting of microcrystalline cellulose (MCC), dicalcium phosphate dihydrate (DCP), hydroxypropyl methylcellulose (HPMC), theophylline and magnesium stearate were prepared. The formulations were granulated using fluid bed granulation and the granules were compacted with the G-HVC method and an eccentric tableting machine. Compaction energy values defined from G-HVC data predicted tensile strength of the tablets surprisingly well. It was also shown, that fluid bed granulation improved the compaction energy intake of the granules in comparison to respective physical mixtures. In addition, general mechanical properties and elastic recovery were also examined for all samples. In this study it was finally concluded, that the data obtained by the method was of practical relevance in pharmaceutical formulation development. Copyright © 2019 Elsevier B.V. All rights reserved.

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