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Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density.

Authors
  • Bradley, John1
  • Stone, Will2, 3
  • Da, Dari F4
  • Morlais, Isabelle5
  • Dicko, Alassane6
  • Cohuet, Anna5
  • Guelbeogo, Wamdaogo M6
  • Mahamar, Almahamoudou5
  • Nsango, Sandrine7
  • Soumaré, Harouna M5
  • Diawara, Halimatou5
  • Lanke, Kjerstin2
  • Graumans, Wouter2
  • Siebelink-Stoter, Rianne2
  • van de Vegte-Bolmer, Marga2
  • Chen, Ingrid8
  • Tiono, Alfred9
  • Gonçalves, Bronner Pamplona3
  • Gosling, Roland8
  • Sauerwein, Robert W2
  • And 3 more
  • 1 MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom. , (United Kingdom)
  • 2 Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands. , (Netherlands)
  • 3 Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom. , (United Kingdom)
  • 4 Institut de Recherche en Sciences de la Santé, Direction, Bobo Dioulasso, Burkina Faso. , (Burkina Faso)
  • 5 Institut de recherche pour le développement, MIVEGEC (UM-CNRS 5290-IRD 224), Montpellier, France. , (France)
  • 6 Malaria Research and Training Centre, Faculty of Pharmacy and Faculty of Medicine and Dentistry, University of Science, Techniques and Technologies of Bamako, Bamako, Mali. , (Mali)
  • 7 Faculté de Médecine et des Sciences Pharmaceutiques, Université de Douala, Douala, Cameroon. , (Cameroon)
  • 8 Global Health Group, Malaria Elimination Initiative, University of California, San Francisco, San Francisco, United States. , (United States)
  • 9 Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso. , (Burkina Faso)
  • 10 MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, United Kingdom. , (United Kingdom)
Type
Published Article
Journal
eLife
Publisher
"eLife Sciences Organisation, Ltd."
Publication Date
May 31, 2018
Volume
7
Identifiers
DOI: 10.7554/eLife.34463
PMID: 29848446
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Understanding the importance of gametocyte density on human-to-mosquito transmission is of immediate relevance to malaria control. Previous work (Churcher et al., 2013) indicated a complex relationship between gametocyte density and mosquito infection. Here we use data from 148 feeding experiments on naturally infected gametocyte carriers to show that the relationship is much simpler and depends on both female and male parasite density. The proportion of mosquitoes infected is primarily determined by the density of female gametocytes though transmission from low gametocyte densities may be impeded by a lack of male parasites. Improved precision of gametocyte quantification simplifies the shape of the relationship with infection increasing rapidly before plateauing at higher densities. The mean number of oocysts per mosquito rises quickly with gametocyte density but continues to increase across densities examined. The work highlights the importance of measuring both female and male gametocyte density when estimating the human reservoir of infection. © 2018, Bradley et al.

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