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Predialysis Urea Nitrogen Is a Nutritional Marker of Hemodialysis Patients

Authors
  • Lee, Seung Woo1
  • Yang, Yu Mi1
  • Kim, Hye-Young1, 1
  • Cho, Hyunjeong1
  • Nam, Sang Won1
  • Kim, Sun Moon1, 1
  • Kwon, Soon Kil1, 1
  • 1 .
Type
Published Article
Journal
Chonnam Medical Journal
Publisher
Chonnam National University Medical School
Publication Date
May 25, 2022
Volume
58
Issue
2
Pages
69–74
Identifiers
DOI: 10.4068/cmj.2022.58.2.69
PMID: 35677952
PMCID: PMC9163601
Source
PubMed Central
Keywords
Disciplines
  • Original Article
License
Unknown

Abstract

End-stage renal disease (ESRD) patients on hemodialysis have poor nutritional status and associated problems such as inflammation and sarcopenia. Blood urea nitrogen (BUN) is an important measure of uremic toxins, and urea reduction is a marker of hemodialysis efficacy. However, a low protein diet for lower BUN could aggravate malnutrition in patients, and optimal pre-dialysis BUN is not defined. We investigated the association of pre-dialysis BUN with patients’ comorbidities and the relationship between pre-dialysis BUN and serum albumin as a nutrient marker. Among the 67 patients, the average pre- and post-dialysis BUN were 59.2 and 15.0 mg/dL, respectively, serum creatinine was 10.1 mg/dL, and the average serum albumin was 4.0 g/dL. Patients’ age was negatively correlated with serum creatinine (r=−0.277, p<0.05) and albumin (r=−0.453, p<0.001). Predialysis BUN showed a significant positive correlation with serum albumin (r=0.287, p<0.05) and creatinine (r=0.454, p<0.001). However, the predialysis BUN was not significantly related to diabetes, coronary artery disease, congestive heart failure, or cerebrovascular disease. Hemodialysis patients with high pre-dialysis BUN and high serum creatinine could be regarded as having good nutritional status. The significance of this study lies in the potential utility of pre-dialysis blood urea nitrogen as an indicator of the nutritional status of patients. Liberal protein intake might be recommended to adequately dialyzed patients.

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