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Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study

  • Kelly, Rachel S.1, 2
  • Kiviranta, Hannu3
  • Bergdahl, Ingvar A.4
  • Palli, Domenico5
  • Johansson, Ann-Sofie6
  • Botsivali, Maria7
  • Vineis, Paolo2, 8
  • Vermeulen, Roel9
  • Kyrtopoulos, Soterios A.7
  • Chadeau-Hyam, Marc2
  • 1 Brigham and Women’s Hospital and Harvard Medical School, Channing Division of Network Medicine, Department of Medicine, 181 Longwood Avenue, Boston, MA, 02115, USA , Boston (United States)
  • 2 Imperial College London, Department of Epidemiology and Biostatistics, London, UK , London (United Kingdom)
  • 3 National Institute for Health and Welfare Chemicals and Health Unit, Neulanen Research Centre, Neulaniementie 4, Kuopio, FI-70210, Finland , Kuopio (Finland)
  • 4 Umeå University, Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå, Sweden , Umeå (Sweden)
  • 5 Cancer Prevention and Research Institute (ISPO), Molecular and Nutritional Epidemiology Unit, Florence, Italy , Florence (Italy)
  • 6 Umeå University, Department of Radiation Sciences, Oncology, Umeå, Sweden , Umeå (Sweden)
  • 7 National Hellenic Research Foundation, Institute of Biology, Pharmaceutical Chemistry and Biotechnology, Athens, Greece , Athens (Greece)
  • 8 HuGeF Foundation, Turin, Italy , Turin (Italy)
  • 9 Utrecht University, Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht, The Netherlands , Utrecht (Netherlands)
Published Article
Environmental Health
BioMed Central
Publication Date
Feb 16, 2017
DOI: 10.1186/s12940-017-0214-8
Springer Nature


BackgroundEvidence suggests a largely environmental component to non-Hodgkin’s lymphoma (NHL). Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), DDE and HCB have been repeatedly implicated, but the literature is inconsistent and a causal relationship remains to be determined.MethodsThe EnviroGenoMarkers study is nested within two prospective cohorts EPIC-Italy and the Northern Sweden Health and Disease Study. Six PCB congeners, DDE and HCB were measured in blood plasma samples provided at recruitment using gas-chromatography mass spectrometry. During 16 years follow-up 270 incident cases of B-cell NHL (including 76 cases of multiple myeloma) were diagnosed. Cases were matched to 270 healthy controls by centre, age, gender and date of blood collection. Cases were categorised into ordered quartiles of exposure for each POP based on the distribution of exposure in the control population. Logistic regression was applied to assess the association with risk, multivariate and stratified analyses were performed to identify confounders or effect modifiers.ResultsThe exposures displayed a strong degree of correlation, particularly amongst those PCBs with similar degrees of chlorination. There was no significant difference (p < 0.05) in median exposure levels between cases and controls for any of the investigated exposures. However under a multivariate model PCB138, PCB153, HCB and DDE displayed significant inverse trends (Wald test p-value <0.05). Under stratified analyses these were determined to be driven by males and by the Diffuse Large B-Cell Lymphoma subtype. When considering those in the highest levels of exposure (>90th percentile) the association was null for all POPsConclusionWe report no evidence that a higher body burden of PCBs, DDE or HCB increased the risk of subsequent NHL diagnosis. Significantly inverse associations were noted for males with a number of the investigated POPs. We hypothesize these unexpected relationships may relate to the subtype composition of our population, effect modification by BMI or other unmeasured confounding. This study provides no additional support for the previously observed role of PCBs, DDE and HCB as risk factors for NHL.

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