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Precursor T cell leukemia--immunological, cytochemical and morphological studies.

Authors
  • Morita, T
  • Morita, R
  • Takagi, S
  • Shimoyama, N
  • Nagai, K
Type
Published Article
Journal
Acta pathologica japonica
Publication Date
Jan 01, 1981
Volume
31
Issue
1
Pages
161–166
Identifiers
PMID: 6972149
Source
Medline
License
Unknown

Abstract

A case of acute lymphoblastic leukemia with a giant splenomegaly in an 8-year-old boy was investigated by immunological, cytochemical and electronmicroscopical techniques. Bone marrow and peripheral blood were largely replaced by large blast cells with a nonconvoluted nucleus. Cytochemically, most of the blast cells showed strong focal acid phosphatase activity. In the surface marker studies, these blast cells formed EAC rosettes but not E rosettes, while they showed positive reactivity with anti-T lymphocyte serum but not with anti-B lymphocyte serum. This membrane phenotype E-, C3R+, T+, B- suggested that leukemic blast cells in this patient presumably originated from precursor T cells.

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