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Preconditioning stimuli and inadvertent preconditioning.

Authors
  • Kloner, R A
  • Przyklenk, K
  • Whittaker, P
  • Hale, S
Type
Published Article
Journal
Journal of molecular and cellular cardiology
Publication Date
Feb 01, 1995
Volume
27
Issue
2
Pages
743–747
Identifiers
PMID: 7776379
Source
Medline
License
Unknown

Abstract

There are several factors besides brief episodes of total coronary occlusion which can provide sufficient stress to result in a preconditioning-like effect on the size of a myocardial infarction. Partial coronary artery stenosis, hypoxia, stretch, catecholamines, rapid pacing, and certain pharmacologic therapies may provide preconditioning stimuli. These same factors as well as mechanical complications in which a coronary artery is briefly occluded or stenosed prior to a subsequent coronary occlusion may lead to inadvertent preconditioning and confound the results of experimental cardiology studies.

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