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Preclinical studies of gossypol in prostate carcinoma.

Authors
  • Naik, H
  • Petrylak, D
  • Yagoda, A
  • Lehr, J
  • Akhtar, A
  • Pienta, K
Type
Published Article
Journal
International journal of oncology
Publication Date
Jan 01, 1995
Volume
6
Issue
1
Pages
209–213
Identifiers
PMID: 21556526
Source
Medline
License
Unknown

Abstract

Hormone refractory prostate cancer remains an incurable disease and the discovery of newer agents with higher cytotoxic activity is required. Gossypol is a phenolic compound isolated from cottonseed oil which has been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell line MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP and DU-145. In vive, gossypol appeared to inhibit tumor growth of subcutaneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic prostate cancer.

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