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Preclinical evaluation of sunitinib as single agent or in combination with chemotherapy in nasopharyngeal carcinoma.

Authors
  • Hui, Edwin Pun
  • Lui, Vivian W Y
  • Wong, Cesar S C
  • Ma, Brigette B Y
  • Lau, Cecilia P Y
  • Cheung, Crystal S F
  • Ho, Kakiu
  • Cheng, Suk-Hang
  • Ng, Margaret H L
  • Chan, Anthony T C
Type
Published Article
Journal
Investigational New Drugs
Publisher
Springer-Verlag
Publication Date
Dec 01, 2011
Volume
29
Issue
6
Pages
1123–1131
Identifiers
DOI: 10.1007/s10637-010-9451-1
PMID: 20467883
Source
Medline
License
Unknown

Abstract

Single agent sunitinib demonstrated potent in vitro and in vivo growth inhibition in NPC. When combined with chemotherapy, sequential instead of concurrent administration schedule should be further explored.

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