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Preclinical disease and preventive strategies in IBD.

Authors
  • Morão, Bárbara1
  • Torres, Joana2
  • 1 Hospital Beatriz Ângelo, Loures, Lisbon, Portugal. , (Portugal)
  • 2 Hospital Beatriz Ângelo, Loures, Lisbon, Portugal; Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: [email protected] , (Portugal)
Type
Published Article
Journal
Current opinion in pharmacology
Publication Date
Nov 19, 2020
Volume
55
Pages
110–115
Identifiers
DOI: 10.1016/j.coph.2020.10.001
PMID: 33221629
Source
Medline
Language
English
License
Unknown

Abstract

There is growing evidence that inflammatory bowel disease has a preclinical phase that precedes disease symptoms, during which immune system activation has already occurred and inflammatory pathways have been primed, setting the stage for disease to expand and leading up to clinical diagnosis. Gaining insight to this pre-diagnosis period could improve our knowledge about disease pathogenesis and potentially result in the detection of biomarkers that could predict disease development. The ultimate goal of such research is to identify a population at risk for developing IBD, so preventive strategies could be implemented and disease prevention be achieved. Copyright © 2020 Elsevier Ltd. All rights reserved.

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