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Preclinical and clinical evaluation of 5-fluorouracil biochemical modulation with folinic acid and hydroxyurea for patients with colorectal carcinoma.

Authors
  • Matei, D
  • Hagag, N
  • Madajewicz, S
  • Chowhan, N
  • Hentschel, P
  • Avvento, L
  • Burns, P
  • Fiore, J
  • Lipera, W
  • Zarrabi, H
Type
Published Article
Journal
Cancer
Publication Date
Oct 15, 1995
Volume
76
Issue
8
Pages
1330–1335
Identifiers
PMID: 8620405
Source
Medline
License
Unknown

Abstract

The biochemical modulation of 5-FU with FA and HU were significantly effective in treating patients with metastatic colorectal carcinoma. Overall, this regimen was well tolerated with only moderate toxicity. Further studies incorporating intravenous HU as well as a randomized Phase III study of 5-FU/FA/HU versus 5-FU/FA are recommended.

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