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Preclinical assessment of a zwitterionic tantalum oxide nanoparticle X-ray contrast agent.

Authors
  • Bonitatibus, Peter J Jr
  • Torres, Andrew S
  • Kandapallil, Binil
  • Lee, Brian D
  • Goddard, Greg D
  • Colborn, Robert E
  • Marino, Michael E
Type
Published Article
Journal
ACS Nano
Publisher
American Chemical Society
Publication Date
Aug 28, 2012
Volume
6
Issue
8
Pages
6650–6658
Identifiers
DOI: 10.1021/nn300928g
PMID: 22768795
Source
Medline
License
Unknown

Abstract

Tantalum oxide nanoparticles show great potential as the next generation of X-ray contrast media. Recently, we reported advances in tantalum oxide nanoparticles and identified improvements that were required for such particles to progress further. Namely, the viscosity of concentrated particles, the amount of retention in reticuloendothelial (RES) tissues, and the effect of large quantities of particles on the kidneys after administration were all identified as critical factors which needed further study, understanding, and development. Here, we report on a zwitterionic siloxane polymer nanoparticle coating that reduced the viscosity of concentrated solutions of particles by a factor of 5, decreased tissue retention of injected particles by a factor of 10, and, importantly, did not induce pathological responses in the kidneys.

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