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Pre-existing endothelial cell activation predicts vasoplegia after mitral valve surgery.

Authors
  • Kortekaas, Kirsten A
  • Lindeman, Jan H N
  • Reinders, Marlies E J
  • Palmen, Meindert
  • Klautz, Robert J M
  • de Groot, Philip G
  • Roest, Mark
Type
Published Article
Journal
Interactive Cardiovascular and Thoracic Surgery
Publisher
Oxford University Press
Publication Date
Sep 01, 2013
Volume
17
Issue
3
Pages
523–530
Identifiers
DOI: 10.1093/icvts/ivt243
PMID: 23736659
Source
Medline
Keywords
License
Unknown

Abstract

Pre-existing endothelial cell activation, reflected by higher baseline von Willebrand Factor propeptide and sP-selectin levels, is a predisposing factor for post-cardiac surgery vasoplegia. The pre-existing endothelial cell activation may have resulted in desensibilization of endothelium in patients who develop vasoplegic syndrome, resulting in no myocardial release of endothelial cell activation markers upon reperfusion.

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