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Pragmatic consideration of recent randomized, placebo-controlled clinical trials for treatment of fibromyalgia.

Authors
Type
Published Article
Journal
Current pain and headache reports
Publication Date
Volume
12
Issue
6
Pages
393–398
Identifiers
PMID: 18973730
Source
Medline
License
Unknown

Abstract

A flurry of recent randomized, placebo-controlled trials assessing dissimilar pharmacotherapeutic treatment options for fibromyalgia (FM) have been presented in the past few years. This review evaluates these trials in light of recent pathophysiological concepts germane to FM, including mood disorders, autonomic dysregulation, altered sleep stage architecture, and the diagnostic tender point controversy. Studies with gabapentin, pregabalin, duloxetine, milnacipran, sodium oxybate, and pramipexole for treatment of FM are discussed.

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