A practical synthesis of 3-[(1R)-1-t-butyldimethylsilyloxyethyl]-4-[(2R)- 4-halo-3-oxo-2-butyl]azetidinone, a versatile intermediate for carbapenem antibiotics.
- Published Article
Bioorganic & Medicinal Chemistry Letters
- Publication Date
Feb 03, 1998
A key intermediate for 2-(functionalized-methyl)-1-beta-methylcarbapenems, 3-[(1R)-1-t-butyldimethylsilyloxyethyl]-4-[(2R)- 4-halo-3-oxo-2-butyl]azetidinone, was prepared efficiently from a commercially available carboxylic acid in 3 steps.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/9871664