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A practical review of the neuropathology and neuroimaging of multiple sclerosis.

Authors
  • Matthews, Paul M1
  • Roncaroli, Frederico2
  • Waldman, Adam1
  • Sormani, Maria Pia3
  • De Stefano, Nicola4
  • Giovannoni, Gavin5
  • Reynolds, Richard1
  • 1 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.
  • 2 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK Division of Neuroscience, University of Manchester, Manchester, UK.
  • 3 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK University of Genoa, Genoa, Liguria, Italy.
  • 4 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
  • 5 Queen Mary College London, London, UK.
Type
Published Article
Journal
Practical neurology
Publication Date
August 2016
Volume
16
Issue
4
Pages
279–287
Identifiers
DOI: 10.1136/practneurol-2016-001381
PMID: 27009310
Source
Medline
Keywords
License
Unknown

Abstract

The variability in the severity and clinical course of multiple sclerosis (MS) has as its basis an extreme heterogeneity in the location, nature and extent of pathology in the brain and spinal cord. Understanding the underlying neuropathology and associated pathogenetic mechanisms of the disease helps to communicate the rationale for treatment and disease monitoring to patients. Neuroimaging is an important tool for this: it allows clinicians to relate neuropathological changes to clinical presentations and to monitor the course of their disease. Here, we review MS neuropathology and its imaging correlates to provide a practical guide for using MRI to assess disease severity and treatment responses. This provides a foundation for optimal management of patients based on the principle that they show 'no evidence of disease activity'.

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