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Practical methods for improving flow properties of active pharmaceutical ingredients.

Authors
  • Pingali, Kalyana C
  • Saranteas, Kostas
  • Foroughi, Reza
  • Muzzio, Fernando J
Type
Published Article
Journal
Drug Development and Industrial Pharmacy
Publisher
Informa UK (Taylor & Francis)
Publication Date
Dec 01, 2009
Volume
35
Issue
12
Pages
1460–1469
Identifiers
DOI: 10.3109/03639040903025830
PMID: 19929205
Source
Medline
License
Unknown

Abstract

Drug powders with improved flow were found to exhibit low dilation and low impedance values. A common linear correlation between flow index and impedance and also between dilation and impedance was observed for all three APIs, indicating that electric properties play a substantial role in the cohesivity of all three APIs, and suggesting the presence of a common mechanism for the emergence (and mitigation) of cohesive phenomena.

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