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PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice

Authors
  • Holt, Marie K.1
  • Cook, Daniel R.1
  • Brierley, Daniel I.1
  • Richards, James E.1
  • Reimann, Frank2
  • Gourine, Alexander V.1
  • Marina, Nephtali1
  • Trapp, Stefan1
  • 1 & Pharmacology, UCL, London, UK
  • 2 Wellcome Trust/MRC Institute of Metabolic Science (IMS), Addenbrookes Hospital, University of Cambridge, Cambridge, UK
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
May 21, 2020
Volume
39
Identifiers
DOI: 10.1016/j.molmet.2020.101024
PMID: 32446875
PMCID: PMC7317700
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Activation of PPG neurons triggers increases in heart rate in mice. • PPG neurons do not provide a tonic sympathetic drive to the heart. • The tachycardic effect of systemic Ex-4 is not mediated by PPG neurons. • GLP-1 receptor activation has a sympathoexcitatory effect that increases heart rate. • Local activation of GLP-1R in the spinal cord is sufficient to elicit tachycardia.

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