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The power of FDG-PET to detect treatment effects is increased by glucose correction using a Michaelis constant.

Authors
  • Williams, Simon-Peter1
  • Flores-Mercado, Judith E
  • Baudy, Andreas R
  • Port, Ruediger E
  • Bengtsson, Thomas
  • 1 Department of Biomedical Imaging, Genentech, Inc,, 1 DNA Way, South San Francisco, CA, 94080, USA. [email protected]
Type
Published Article
Journal
EJNMMI Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jun 27, 2012
Volume
2
Issue
1
Pages
35–35
Identifiers
DOI: 10.1186/2191-219X-2-35
PMID: 22738240
Source
Medline
License
Unknown

Abstract

When evaluating the direct effects of treatment on tumor tissue with FDG-PET, employing a Michaelis-Menten glucose correction factor gives the most statistically powerful results. The well-known alternative 'correction', multiplying Ki by blood glucose (or normalized blood glucose), appears to be counter-productive in this setting and should be avoided.

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