Affordable Access

Power of the classical twin design revisited.

Authors
Type
Published Article
Journal
Twin research : the official journal of the International Society for Twin Studies
Publication Date
Volume
7
Issue
5
Pages
505–512
Identifiers
PMID: 15527666
Source
Medline
License
Unknown

Abstract

Statistical power of the classical twin design was revisited. The approximate sampling variances of a least-squares estimate of the heritability in a univariate analysis and estimate of the genetic correlation coefficient in a bivariate analysis were derived analytically for the ACE model. Statistical power to detect additive genetic variation under the ACE model was derived analytically for least-squares, goodness-of-fit and maximum likelihood-based test statistics. The noncentrality parameter for the likelihood ratio test statistic is shown to be a simple function of the MZ and DZ intraclass correlation coefficients and the proportion of MZ and DZ twin pairs in the sample. All theoretical results were validated using simulation. The derived expressions can be used to calculate power of the classical twin design in a simple and rapid manner.

Statistics

Seen <100 times