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Potentiation of fungicidal activities of trans-anethole against Saccharomyces cerevisiae under hypoxic conditions.

Authors
  • Fujita, Ken-Ichi
  • Kubo, Isao
Type
Published Article
Journal
Journal of Bioscience and Bioengineering
Publisher
Elsevier
Publication Date
Jan 01, 2004
Volume
98
Issue
6
Pages
490–492
Identifiers
PMID: 16233742
Source
Medline
License
Unknown

Abstract

A naturally occurring phenylpropanoid, trans-anethole (anethole), was assayed for its fungicidal activity in Saccharomyces cerevisiae grown under hypoxic and aerobic conditions. Anethole killed the growing cells in malt extract broth only under hypoxic conditions. Anethole did not exhibit fungicidal effects against non-growing cells. The cells of a mitochondrial-DNA-lacking rho0 mutant, which grew fermentatively even in the presence of O2, were killed by anethole regardless of aeration. The fungicidal potency of anethole against a strain capable of respiration under aerobic conditions was enhanced by the addition of a respiratory inhibitor antimycin A3. Therefore, anethole possibly expresses fungicidal activities only against fermentatively growing cells of S. cerevisiae.

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