Affordable Access

Potentiation of the adrenergic beta-receptor-mediated insulin secretion in pertussis-sensitized rats.

Authors
  • Sumi, T
  • Ui, M
Type
Published Article
Journal
Endocrinology
Publication Date
Aug 01, 1975
Volume
97
Issue
2
Pages
352–358
Identifiers
PMID: 1157756
Source
Medline
License
Unknown

Abstract

The increase in blood insulin level induced by adrenergic beta-stimulants, glucose and tolbutamide was strongly exaggerated in pertussis-sensitized rats. Moreover, the decrease in blood insulin caused by the alpha-receptor-mediated action of epinephrine in glucose- or tolbutamide-treated rats was effectively reversed by pertussis sensitization. The rise of blood insulin concentration due to adrenergic alpha-blockade was also enhanced by pertussis sensitization. It is concluded that the secretion of insulin resulting from the stimulation of adrenergic bate-receptor is enhanced by pertussis sensitization, probably due to activation of a process occurring in the chain of events leading to the discharge of insulin from the pancreatic beta-cell.

Report this publication

Statistics

Seen <100 times