Affordable Access

deepdyve-link
Publisher Website

The Potential Value of the PI3K/Akt/mTOR Signaling Pathway for Assessing Prognosis in Cervical Cancer and as a Target for Therapy.

Authors
  • Bahrami, Afsane1, 2
  • Hasanzadeh, Malihe3
  • Hassanian, Seyed Mahdi4, 5
  • ShahidSales, Soodabeh6
  • Ghayour-Mobarhan, Majid4
  • Ferns, Gordon A7
  • Avan, Amir4, 6
  • 1 Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
  • 2 Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
  • 3 Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
  • 4 Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
  • 5 Department of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
  • 6 Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
  • 7 Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
Type
Published Article
Journal
Journal of Cellular Biochemistry
Publisher
Wiley (John Wiley & Sons)
Publication Date
Dec 01, 2017
Volume
118
Issue
12
Pages
4163–4169
Identifiers
DOI: 10.1002/jcb.26118
PMID: 28475243
Source
Medline
Keywords
License
Unknown

Abstract

Cervical cancer is a common gynecological cancer and a leading cause of cancer-related death in women globally. There is a need for the identification of prognostic and predictive biomarker for risk stratification. The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is often dysregulated in cervical cancer, indicating that it may be a potential therapeutic target in the treatment of this malignancy, and could perhaps be used as a novel biomarker in the assessment of risk of developing cervical cancer. We aimed to provide an overview of the potential applications of the PI3K/Akt/mTOR pathway as biomarker for risk stratification, in predicting the prognosis of cervical cancer, and for developing new therapeutic approaches in patients with cervical cancer. J. Cell. Biochem. 118: 4163-4169, 2017. © 2017 Wiley Periodicals, Inc.

Report this publication

Statistics

Seen <100 times