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Potential Utility of Systemic Plasma Biomarkers for Evaluation of Pediatric Schistosomiasis in Western Kenya

Authors
  • Ondigo, Bartholomew N.1
  • Hamilton, Rachael E.2, 3
  • Magomere, Edwin O.1
  • Onkanga, Isaac O.4
  • Mwinzi, Pauline N.5
  • Odiere, Maurice R.4
  • Ganley-Leal, Lisa3
  • 1 Department of Biochemistry and Molecular Biology, Faculty of Science, Egerton University, Egerton , (Kenya)
  • 2 School of Public Health, Boston University, Boston, MA , (United States)
  • 3 Global Development, Elegance Biotechnologies, Wayne, PA , (United States)
  • 4 Centre for Global Health Research, Kenya Medical Research Institute (KEMRI), Kisumu , (Kenya)
  • 5 Regional Office for Africa, World Health Organization, Brazzaville
Type
Published Article
Journal
Frontiers in Immunology
Publisher
Frontiers Media SA
Publication Date
May 06, 2022
Volume
13
Identifiers
DOI: 10.3389/fimmu.2022.887213
Source
Frontiers
Keywords
Disciplines
  • Immunology
  • Original Research
License
Green

Abstract

Introduction Current diagnostic tools for schistosomiasis are limited, and new tests are necessary to enhance disease diagnosis and surveillance. Identification of novel disease-specific biomarkers may facilitate the development of such tests. We evaluated a panel of biomarkers used in sepsis and parasitic diseases for their potential suitability in the diagnosis of schistosomiasis. Objective The study evaluated the levels of systemic plasma biomarkers in relation to Schistosoma mansoni infection and parasite burden. Methods Six biomarkers were measured in the plasma of children from schistosomiasis-endemic regions using ELISA. The concentration of soluble CD23 (sCD23) and lipopolysaccharide (LPS) was tested in 199 and 124 plasma samples, respectively, while interleukin-6 (IL-6), soluble triggering receptor expressed on myeloid (sTREM) cells, eotaxin-1, and fatty acid-binding protein (FABP) concentrations were tested in 30 plasma samples. Results The concentration of IL-6, eotaxin-1, FABP, and LPS was similar between schistosome-infected and uninfected children. The schistosome-infected children had higher median levels of sTREM and sCD23 as compared to uninfected children, 119.0 (29.9–208.9) versus 10.7 (0.0–73.4) (p = 0.046) and 2,549.0 (1,899.0–3,356.0) vs. 2,035.0 (1,448.0–2,939.0) (p = 0.05), respectively. In addition, sTREM was positively correlated with egg density (p = 0.017). Conclusion Our data show that active schistosomiasis per se is associated with elevated levels of sTREM and sCD23. sTREM has potential diagnostic and prognostic values. However, these biomarkers did not distinguish between children with low egg burden and uninfected children.

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