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Potential use of Sox9 gene therapy for intervertebral degenerative disc disease.

Authors
  • Paul, Ronjon
  • Haydon, Rex C
  • Cheng, Hongwei
  • Ishikawa, Akira
  • Nenadovich, Nikola
  • Jiang, Wei
  • Zhou, Lan
  • Breyer, Benjamin
  • Feng, Tao
  • Gupta, Purnendu
  • He, Tong-Chuan
  • Phillips, Frank M
Type
Published Article
Journal
Spine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Apr 15, 2003
Volume
28
Issue
8
Pages
755–763
Identifiers
PMID: 12698117
Source
Medline
License
Unknown

Abstract

A novel adenoviral vector efficiently increased Sox9 and Type 2 collagen synthesis in cultured chondroblastic cells and human degenerated disc cells. In a rabbit model, sustained Sox9 production preserved the histologic appearance of the nucleus pulposus cells in vivo. These findings suggest a potential role for Sox9 gene therapy in the treatment of human degenerative disc disease.

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