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The potential use of natural products to negate hepatic, renal and neuronal toxicity induced by cancer therapeutics.

Authors
  • Prša, Patrik1
  • Karademir, Betül2
  • Biçim, Gökhan3
  • Mahmoud, Hatem4
  • Dahan, Inbal5
  • Yalçın, A Süha6
  • Mahajna, Jamal7
  • Milisav, Irina8
  • 1 University of Ljubljana Faculty of Medicine, Institute of Pathophysiology, Zaloška 4, SI-1000 Ljubljana, Slovenia. , (Slovenia)
  • 2 Department of Biochemistry, School of Medicine/Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, Istanbul, Turkey. Electronic address: [email protected] , (Turkey)
  • 3 Department of Biochemistry, School of Medicine/Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, Istanbul, Turkey. , (Turkey)
  • 4 The Department of Nutrition and Natural Products, Migal-Galilee Research Institute, Kiryat Shmona 11016, Israel; Department of Nutritional Sciences, Faculty of Sciences and Technology, Tel-Hai College, Kiryat Shmona, Israel. , (Israel)
  • 5 The Department of Nutrition and Natural Products, Migal-Galilee Research Institute, Kiryat Shmona 11016, Israel. , (Israel)
  • 6 Department of Biochemistry, School of Medicine/Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, Istanbul, Turkey. Electronic address: [email protected] , (Turkey)
  • 7 The Department of Nutrition and Natural Products, Migal-Galilee Research Institute, Kiryat Shmona 11016, Israel; Department of Nutritional Sciences, Faculty of Sciences and Technology, Tel-Hai College, Kiryat Shmona, Israel. Electronic address: [email protected] , (Israel)
  • 8 University of Ljubljana Faculty of Medicine, Institute of Pathophysiology, Zaloška 4, SI-1000 Ljubljana, Slovenia; University of Ljubljana, Faculty of Health Sciences, Laboratory of Oxidative Stress Research, Zdravstvena pot 5, SI-1000 Ljubljana, Slovenia. Electronic address: [email protected] , (Slovenia)
Type
Published Article
Journal
Biochemical pharmacology
Publisher
New York, NY : Elsevier Science Inc
Publication Date
Mar 01, 2020
Volume
173
Pages
113551–113551
Identifiers
DOI: 10.1016/j.bcp.2019.06.007
PMID: 31185225
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Different types of chemotherapeutics are used for cancer treatment. These drugs act on several signal pathways, lead to programmed cell death, and damage cancer cells. Although many specific mechanisms of action have been suggested for chemotherapeutics, there are still gaps in understanding their effects. They may affect different components of the cell, particularly proteins with specific functions, such as enzymes. Recently, targeted and immuno therapies were introduced for treatment of different cancers. However, many cancer patients still depend on traditional and well-known drugs. Doxorubicin and platinum-based drugs are among the most frequently used chemotherapeutics. They are highly cytotoxic for cancer cells, but they also act on healthy cells. Hence, it is crucial to understand the mechanisms involved in order to decrease their side effects. Natural products, many of which are also available over-the-counter, may be considered to decrease various cancer drug-induced side effects. This review focuses on the use of these compounds to overcome side effects of chemotherapeutics, primarily doxorubicin and cisplatin, in the liver, kidney, and neuronal systems. Copyright © 2019 Elsevier Inc. All rights reserved.

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