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The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage.

Authors
  • Xu, Bo-Yang1
  • Jin, Yu2
  • Ma, Xiao-Hui3
  • Wang, Chi-Yu4
  • Guo, Yi2, 5, 6
  • Zhou, Dan1, 5, 6
  • 1 School of Acupuncture-Moxibustion and Tuina, 58301Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China. , (China)
  • 2 School of Chinese Medicine, 58301Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China. , (China)
  • 3 School of Culture and Health Communication, 58301Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China. , (China)
  • 4 Department of Electrical Engineering and Computer Sciences, 1438University of California, Berkeley, CA, USA.
  • 5 Research Center of Experimental Acupuncture Science, 58301Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China. , (China)
  • 6 National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, People's Republic of China. , (China)
Type
Published Article
Journal
Journal of orthopaedic surgery (Hong Kong)
Publication Date
Jan 01, 2020
Volume
28
Issue
3
Identifiers
DOI: 10.1177/2309499020950262
PMID: 32840428
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Biomechanical factors play an extremely important role in regulating the function of articular chondrocytes. Understanding the mechanical factors that drive chondrocyte biological responses is at the heart of our interpretation of cascade events leading to changes in articular cartilage osteoarthritis. The mechanism by which mechanical load is transduced into intracellular signals that can regulate chondrocyte gene expression remains largely unknown. The mechanically sensitive ion channel (MSC) may be one of its specific mechanisms. This review focuses on four ion channels involved in the mechanotransduction of chondrocytes, exploring their properties and the main factors that activate the associated pathways. The upstream and downstream potential relationships between the protein pathways were also explored. The specific biophysical mechanism of the chondrocyte mechanical microenvironment is becoming the focus of research. Elucidating the mechanotransduction mechanism of MSC is essential for the research of biophysical pathogenesis and targeted drugs in cartilage injury-related diseases.

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