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[The potential role of high mobility group box 1 protein in immune dysfunction and its regulatory mechanism after major trauma].

Authors
  • Yao, Yong-ming
  • Lin, Hong-yuan
Type
Published Article
Journal
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Publication Date
Sep 01, 2008
Volume
20
Issue
9
Pages
513–515
Identifiers
PMID: 18786304
Source
Medline
License
Unknown

Abstract

These data proved that HMGB1 not only acts as a novel "late" inflammatory mediator but is also closely associated with immunosuppression after acute insults. HMGB1 might play an important role in inducing systemic inflammatory response together with host immunological dissonance, resulting in the development of septic complications. Intervention of HMGB1 expression and release presumably provides a potentially effective way to regulate both excessive inflammatory and immune response, thereby as a measure to improve the prognosis of severe sepsis secondary to major trauma.

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