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The potential role of the esophageal pre-epithelial barrier components in the maintenance of integrity of the esophageal mucosa in patients with endoscopically negative gastroesophageal reflux disease.

Authors
  • Marcinkiewicz, M
  • Han, K
  • Zbroch, T
  • Poplawski, C
  • Gramley, W
  • Goldin, G
  • Sarosiek, J
Type
Published Article
Journal
The American journal of gastroenterology
Publication Date
Jul 01, 2000
Volume
95
Issue
7
Pages
1652–1660
Identifiers
PMID: 10925964
Source
Medline
License
Unknown

Abstract

Our data indicate that patients with E (-) GERD have an esophageal secretory potential, in terms of glycoconjugate and protein, higher than that in asymptomatic controls. This phenomenon in patients with E (-) GERD may, by enhancing the quantity of the esophageal pre-epithelial barrier, help to prevent the development of erosive esophagitis. A significantly lower esophageal secretory response in patients with E (-) GERD in terms of nonbicarbonate buffers and TGFalpha may facilitate the development of GERD symptoms and histological changes of GERD, respectively.

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