Affordable Access

Publisher Website

The potential role of B5: A stitch in time and switch in cytokine.

  • Gheita, Alaa A1, 2
  • Gheita, Tamer A3, 4
  • Kenawy, Sanaa A5, 6
  • 1 Plastic Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt. , (Egypt)
  • 2 Egyptian Society of Plastic and Reconstructive Surgeons, Cairo, Egypt. , (Egypt)
  • 3 Rheumatology and Clinical Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. , (Egypt)
  • 4 Graduate Studies and Research Affair, Cairo University, Cairo, Egypt. , (Egypt)
  • 5 Pharmacology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. , (Egypt)
  • 6 Royal College of Surgeons, London University, London, UK.
Published Article
Phytotherapy Research
Wiley (John Wiley & Sons)
Publication Date
Nov 05, 2019
DOI: 10.1002/ptr.6537
PMID: 31691401


The wound healing process is a multifaceted sequence of activities associated with tissue restoration. Novel approaches for the perfection of wound healing have been determined as a stitch in time saves nine. Dysregulation of the immune response is a key element in the pathogenesis of rheumatic diseases and serves as a potential target for novel therapeutic strategies. Vitamin B5 (VB5), also known as pantothenate or "anti-stress vitamin," is the precursor of coenzyme A, which is essential in every micro-organism. Many pantothenic acid amides acquire persuasive antimicrobial activity. Pantothenic acid improves surgical wounds healing with moisturizing and skin barrier enhancing potential. Its deficiency leads to reduced cortisol production, increased arthritic pain, myalgia, fatigue, headache, depression, insomnia, and widespread "proinflammatory" effects on the immune-system. VB5 triggers immune cells to produce cytokines and is multifunctional. The paradoxical effect of VB5 on the switch of anti-inflammatory and proinflammatory cytokines has been revealed. This review aims to present the long research journey of B5 as it is becoming a forerunner in the healing of wounds and in enhancing the immune function, thus providing potentially important therapeutic implications. As its role in healing a wound stitch is promising, amending the immune system damage too is a hopeful target. © 2019 John Wiley & Sons, Ltd.

Report this publication


Seen <100 times