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Potential Mechanism of Action of Cyclosporin A in Human Dermal Fibroblasts—Transcriptomic Analysis of CYPs

Authors
  • Janikowska, Grażyna
  • Pyka-Pająk, Alina
  • Janikowski, Tomasz
  • Adamska, Jolanta
  • Mazurek, Urszula
  • Jędrusik, Przemysław
Publication Date
Jul 05, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

0.05. Comparing the samples from fibroblasts cultured with CsA and those cultured without, up-regulated changes of CYP19A1, 1B1, 7A1, 7F1, 17A1 and down-regulated 2D6 gene expression were observed. The mRNAs with increased changes were in the same neuron of the self-organizing feature map. All distinguished CYPs encode monooxygenases, which plays an important role in steroids biosynthesis and metabolism. Based on the obtained results, we can conclude that CsA in therapeutic concentration changes the expression profile of CYPs in human dermal fibroblasts, especially affecting genes linked to steroids synthesis and/or metabolism. It shows the potential mechanism of action of CsA in human dermal fibroblast cells.

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